SecondWave Systems
Minneapolis, MinnesotaFounded 2019
- Neuromodulation
- Wearables
SecondWave Systems is a medical technology company developing innovative, personalized therapies for chronic conditions. Its approach combines ultrasound technology with neural and immune modulation to create cost-effective, less invasive treatments designed to reduce the side effects associated with traditional interventions.
- TrialClinical trial
- 1
- Founded
- 2019
- Employees
- 11–50
reccy insights
SecondWave Systems’ most notable disclosed milestones in 2025 centered on financing and visibility for its ultrasound-based anti-inflammatory approach. On April 8, the company raised $7 million in a Series A led by Treo Ventures, with participation from SSBCI fund, University of Minnesota Discovery Capital Investment, and Scientific Health Development Partners. On June 9, IEEE Spectrum published “Doctors Could Hack the Nervous System With Ultrasound,” bringing attention to the broader potential of focused ultrasound to influence neural and inflammatory pathways. These financing milestones followed a $3 million grant from the Advanced Research Projects Agency for Health on March 27, 2024, and a $7 million Seed round led by the Department of Defense in April 2021. The company describes its platform as non-invasive, low-intensity focused ultrasound intended to modulate nerves, cells, and organs.
Written by reccy's AI from company sites, press and funding records · updated Oct 2026
What makes SecondWave Systems distinct
- 01Develops non-invasive therapeutic interventions using low-intensity focused ultrasound.
- 02Targets neural and immune modulation for potential treatment of inflammation, pain, and other conditions.
- 03Combines ultrasound with wearable therapy concepts designed for treatment outside frequent office visits.
- 04Describes proprietary sensing and imaging capabilities for adaptive, personalized treatment.
- 05Focuses on bioelectric medicine as an alternative therapeutic approach to conventional interventions.
Technology & products3
- Noninvasive Ultrasound Stimulation Platform
A wearable device that uses low-intensity focused ultrasound to modulate nerves, cells, and organs for treating various conditions.
- Wearable Ultrasound Therapy
A miniaturized, in-home self-administration solution that reduces the need for frequent office visits.
- Adaptive and Personalized Therapy
A platform with proprietary sensing and imaging capabilities for personalized treatment.
Clinical trials1
- At-home Ultrasound Localized Therapy for Rheumatoid Arthritis Study [At-home ULTRA Study]Active, not recruitingNCT07163221 · 60 participants · started Nov 2025
- Rheumatoid Arthritis (RA)
In the Cortex
- Mark Gryzwa Appointed VP of Product Development at SecondWave SystemsSecondWave Systems on LinkedIn · Feb 12, 2026
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About SecondWave Systems
- Products
- Noninvasive Ultrasound Stimulation Platform, Wearable Ultrasound Therapy, Adaptive and Personalized Therapy
- Leadership
- Anuj Bhardwaj, CEO & Founder
- Focus areas
- Medical devices, therapeutics, ultrasound, neuromodulation, immune modulation, bioelectric medicine, wearable technology, chronic conditions
- Headquarters
- Minneapolis, Minnesota
- Founded
- 2019
- Employees
- 11–50